Prescription muscle relaxers like cyclobenzaprine and baclofen are typically used for more severe muscle spasms and pain. They are stronger and require a doctor's supervision due to potential side effects and risks. Over-the-counter options, such as nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen, can provide relief for mild muscle pain and inflammation. While OTC options are more accessible, they are less potent. It’s essential to choose the right treatment based on the severity of your symptoms and consult with a healthcare professional to determine the best course of action.